The global market for managing cytokine release syndrome (CRS) is poised to reach a significant milestone, with an anticipated valuation of US$ 23.32 billion by 2023. Further, this market is forecasted to maintain a robust growth trajectory, boasting a projected Compound Annual Growth Rate (CAGR) of 6.7% from 2023 to 2033.
This substantial growth is driven by the rising prevalence of autoimmune diseases and cancers, which is expected to propel the demand for CRS management solutions in the foreseeable future.
The landscape of CRS management has witnessed a transformative shift, thanks to the introduction of a new generation of drugs, including tocilizumab, siltuximab, and anakinra. These innovative pharmaceuticals have revolutionized the treatment of Cytokine Release Syndrome by effectively curbing the production of pro-inflammatory cytokines, thereby mitigating the severity of the syndrome. Furthermore, proactive and comprehensive supportive care measures such as fluid resuscitation, anti-emetic therapies, and anti-diarrheal medications have shown promise in alleviating CRS symptoms.
Early recognition and prompt treatment of CRS are pivotal in preventing long-term complications, underscoring the importance of early intervention in this dynamic landscape of CRS management.
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FDA approvals of various therapeutics and drugs have further enhanced the market. Further studies and tests funded by the government will increase awareness of CRS management by clinical professionals. For instance, mosunetuzumab-axgb (Lunsumio; Genentech) was approved by the FDA for the treatment of adults with R/R follicular lymphoma. As of July 2022, mosunetuzumab had been granted priority review by the FDA for the treatment of R/R FL. High and durable responses were demonstrated in the phase 2 GO29781 study (NCT02500407), which supported the decision. The continued approval of this product is dependent on a confirmatory trial verifying clinical benefit since this is an accelerated approval.
Key Takeaways from the Market Study
- Globally, the cytokine release syndrome management market is expected to reach US$ 23.32 billion by 2023.
- Hospitals for cytokine release syndrome management are expected to grow 32% market share between 2023 and 2033.
- The market for Tumour Necrosis Factor-TNF is projected to grow by 2.9% from 2023 to 2033.
- Cytokine release syndrome management in North America expanded with a market share of 17% during the forecast period.
- According to forecasts, the arthritis therapeutics market accumulate a share of 19% over the next few years.
“Advances in immunotherapies, the approval of new drugs, and CAR T-cell therapies are expected to further accelerate the growth of the cytokine release syndrome management market.” comments a Future Market Insights analyst.
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Competitive Landscape
The development of innovative diagnostic techniques is becoming increasingly important for companies, which will probably lead to a number of firms expanding their product lines, acquiring other companies, or merging their companies in the near future, as many are likely to focus on developing new diagnostic techniques.
- Kite announced that the Food and Drug Administration (FDA) has approved the addition of prophylactic corticosteroids to the prescribing information for Yescarta®. The label on Yescarta includes information to guide physicians in managing and possibly preventing side effects associated with chimeric antigen receptor (CAR) T-cell therapies. To maximize the chances of CAR T-cell therapy being beneficial to as many patients as possible, Kite has been working closely with physicians since Yescarta’s first approval in 2012. CAR T therapy research is also focused on expanding into new diseases and early treatment lines, while continuously enhancing the safety and efficacy of existing treatments.
- Nexcella, Inc., a subsidiary of Immix Biopharma, Inc., reported stable response rates among 6 patients with relapsed/refractory AL amyloidosis using NXC-201. Six relapsed/refractory AL amyloidosis patients treated with NXC-201 have shown 100% complete response. Using clinical cancer research, 100% complete responses were observed; 100% organ responses were observed; and at 5.2 months, the duration of response was still unknown, resulting in an average reduction of 65% (2,656 pg/mL) in NT-proBNP from baseline. There was no grade 4 Cytokine Release Syndrome. ICANS neurotoxicity was not observed; NYHA stage improved by 2 stages.
Key Companies Profiled:
- Hoffmann-La Roche Ltd
- GlaxoSmithKline Plc
- Novartis AG
- Sanofi S.A
- Pfizer Inc.
- Bayer AG
- Biocon
- AbbVie Inc.
- Johnson & Johnson Private Limited
- Incyte Corporation
- Swedish Orphan Biovitrum
- Genentech
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Key Segments Profiled in the Cytokine Release Syndrome Management Industry Survey?
By Cytokine Type:
- Tumor Necrosis Factor-TNF
- Interleukins-II
- Interferons-IFN
- Epidermal Growth Factor-EGF
By Therapeutic Application:
- Cancer
- Asthma
- Airway Inflammation
- Arthritis
- Others
By Biomarker Type:
- Interleukin-10
- Interferon Gamma
- Interleukin-6
- Ferritin
- Cluster of Differentiation-163
By Route of Administration:
- Oral
- Intravenous
By End User:
- Hospitals
- Specialty Clinics
- Others
Author
Sabyasachi Ghosh (Associate Vice President at Future Market Insights, Inc.) holds over 12 years of experience in the Healthcare, Medical Devices, and Pharmaceutical industries. His curious and analytical nature helped him shape his career as a researcher.
Identifying key challenges faced by clients and devising robust, hypothesis-based solutions to empower them with strategic decision-making capabilities come naturally to him. His primary expertise lies in areas such as Market Entry and Expansion Strategy, Feasibility Studies, Competitive Intelligence, and Strategic Transformation.
Holding a degree in Microbiology, Sabyasachi has authored numerous publications and has been cited in journals, including The Journal of mHealth, ITN Online, and Spinal Surgery News.
About Future Market Insights (FMI)
Future Market Insights, Inc. (ESOMAR certified, recipient of the Stevie Award, and a member of the Greater New York Chamber of Commerce) offers profound insights into the driving factors that are boosting demand in the market. FMI stands as the leading global provider of market intelligence, advisory services, consulting, and events for the Packaging, Food and Beverage, Consumer Technology, Healthcare, Industrial, and Chemicals markets. With a vast team of over 5,000 analysts worldwide, FMI provides global, regional, and local expertise on diverse domains and industry trends across more than 110 countries.
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