According to a recent Future Market Insights report, the global Gastro-Retentive Drug Delivery Systems Market Size is expected to reach US$ 14 billion by 2023, with a compound annual growth rate of 10.1% from 2023 to 2033, for a market value of US$ 24.8 billion by the end of 2033.
Gastro-Retentive Drug Delivery Systems (GRDDS) are a class of pharmaceutical formulations designed to prolong the residence time of drugs in the stomach. These systems aim to enhance the absorption and bioavailability of drugs with specific requirements, such as drugs with a narrow absorption window or those that are unstable in the acidic environment of the stomach. By prolonging gastric retention, GRDDS ensure a controlled and sustained release of the drug, improving its therapeutic efficacy and reducing the frequency of dosing.
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One approach to achieving gastro-retention is through the use of floating drug delivery systems. These systems contain buoyant materials or gas-generating agents that allow them to remain buoyant on the gastric fluids. As a result, they float on the stomach contents, maintaining contact with the absorption site and extending the drug release. Another strategy involves the use of mucoadhesive systems, which adhere to the gastric mucosa, prolonging the residence time and enabling controlled drug release. These systems can be formulated as tablets, capsules, or multiparticulate dosage forms, providing flexibility in drug delivery.
The advantages of Gastro-Retentive Drug Delivery Systems are manifold. They enhance drug bioavailability, reduce dosing frequency, and improve patient compliance. By maintaining therapeutic drug levels for an extended period, GRDDS offer better control over the release kinetics, ensuring consistent drug concentration in the blood. This is particularly beneficial for drugs with a narrow therapeutic index or those requiring a sustained release profile. Furthermore, GRDDS can also minimize the adverse effects associated with rapid drug release in the upper gastrointestinal tract, such as gastric irritation or local toxicity.
Gastro-Retentive Drug Delivery Systems Market Driving Factors:
Large drug companies’ expenditures in improving Gastro-Retentive Drug Delivery Systems, as well as a reduction in required doses due to improved bioavailability and an increase in medicine requirements, have aided market expansion. The market is influenced by the well-established efficacy of Gastro-Retentive Drug Delivery Systems in treating a variety of stomach disorders such as peptic ulcer and gastric ulcer, as well as an increase in the incidence of H. Pylori infection, which can cause gastritis and gastric cancer.
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Gastro-retentive drug distribution technology has proven to be an effective method of controlling the delivery of a wide range of pharmaceutical compounds while improving bioavailability. In recent years, advances in controlled oral medicine administration systems have been made as a result of technical improvements that have surmounted physical barriers such as unexpected stomach emptying intervals and short gastric residency times. Once-GRDDS can improve oral bioavailability and therapeutic efficacy by increasing their dwell time in the upper GI tract.
Technological advances in rate-controlled oral drug administration systems are now addressing physiological obstacles such as irregular stomach emptying intervals and short gastric residency times. To address these concerns, the gastro-retentive drug delivery system is developed for a longer stomach retention duration, which promotes patient preference by increasing the amount of time available for medicine absorption.
Gastro-Retentive Drug Delivery Systems Market Regional Insights:
With a market prediction of US$ 10 billion, North America is likely to account for significant revenue in the Gastro-Retentive Drug Delivery Systems industry. The development of better gastro-retentive medicine delivery technology and the deployment of revolutionary treatment strategies in healthcare are projected to facilitate regional expansion.
GRDDS are expected to be in high demand as the prevalence of gastrointestinal illnesses rises in the United States and Canada, owing to their ability to extend medicine retention time in the stomach. The availability of a large patient pool is expected to stimulate demand for these devices in the region. Rising R&D spending in emerging markets is likely to drive regional market expansion.
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Gastro-Retentive Drug Delivery Systems Market Competitive Analysis:
Manufacturers will benefit from proprietary benefits such as industry research financing and product development agreements, which will help them contribute to the development of effective cancer diagnosis technologies. Obtaining patents and government clearances for new technology will also continue to be a key growth strategy. The key players in the market include Ranbaxy, F. Hoffmann La Roche, Pharmacia, GlaxoSmithKline, Lupin, Pfizer, Depomed, Galanix, Sun Pharma, and Alcon, Inc.
Few of the recent developments of key Gastro-Retentive Drug Delivery Systems providers are as follows:
- In 2020, Cadila Pharmaceuticals launched Esomeprazole tablets which will be used in treatment of hyperacidity and drug induced gastritis.
- In 2020, Xiromed LLC launched 20mg Omperazole delayed release capsules. Omeprazole is cost effective generic product which can be used in treatment of gastroesophageal reflux disease and healing of erosive esophagitis.
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